COMS [cxii,cxiii,cxiv,cxv,cxvi,cxvii]
Collaborative Ocular Melanoma Study
- Small (1 - 3mm thick, basal diameter < 5mm: 30% grow & mortality 1% 5yrs; Thickness > 2mm, fluid, symptoms, orange pigment, margin within 3mm of optic disc. “TFSOM”
- Medium (3 - 10mm thick, 5 - 16mm basal diameter): brachytherapy = enucleation, mortality with treatment 20%
- Large (> 10mm thick, > 16mm basal diameter): pre-enucleation radiation treatment no effect, mortality with treatment 35%
Monosomy 3 = poor prognosis
1990. Accuracy of Diagnosis of Choroidal Melanomas in the Collaborative Ocular Melanoma Study: COMS Report No. 1. Archives of Ophthalmology 108(9) 1268-1273.
1998. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma I: characteristics of patients enrolled and not enrolled COMS report no. 9. American Journal of Ophthalmology 125(6) 767-778.
1998. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma II: initial mortality findings COMS report no. 10. American Journal of Ophthalmology 125(6) 779-796.
2004. Ten-year follow-up of fellow eyes of patients enrolled in Collaborative Ocular Melanoma Study randomized trials: COMS report no. 22. Ophthalmology 111(5) 966-976.
2006. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report No. 28. Arch Ophthalmol 124(12) 1684-1693.
Collaborative Ocular Melanoma Study, G. 2004. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24. American Journal of Ophthalmology 138(6) 936-951.
